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Objectif Végétal : une dynamique partenariale

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    Biocontrol agents that block the adaptive mechanisms of pathogens

    Phytopathogenic agents face special conditions during their transmission through seeds: chemical stress and physical stress.

    Chemical stresses

    Recent results: 
    • Identification of a phytopathogenic fungal response mechanism to phytoalexins: reinforcement of the fungus wall,
    Potential benefit:

    Using sensitins for the treatment of seeds and seedlings, in synergy with plant resistance inducers (PRIs). 


    Physical stresses

    Recent results:  

    FUNHY project (2014-2016) – funded by RFI Objectif Végétal
    associated with the thesis of Guillaume N'Guyen (2012-2015).

    Identification of 2 response mechanisms of phytopathogenic fungi to water stress:

    • The formation of eisosomes
    • The production of hydrophilins


    Nemofy project including the thesis of Justine Colou (2016-2019) – funded by RFI Objectif Végétal

    Study of the molecular factors involved in the transmission of phytopathogenic fungi to seeds (focus on eisosomes).

    Potential benefit:

    Develop strategies to inhibit this adaptive response of the pathogenic fungus.


    Thomas Guillemette

    thomas.guillemette @ univ-angers.fr



    Biocontrol agents antagonistic to phytopathogenic agents

    NABUCO project (2014-2016)– funded by the French Ministery of Agriculture

    Identification of aggressive marine micro-organisms with phytopathogenic fungi.

    Potential benefit:

    Use these antagonistic agents in biological control on plants and seeds.


    Thomas Guillemette
    thomas.guillemette @ univ-angers.fr



    The microbiota of seeds, a biodiversity to be exploited

    Microbial communities associated with seeds interfere with the transmission of pathogens.


    Recent results:

    MetaSEED project (2014-2016) IRHSHM ClauseVilmorinfunded by Région Pays de la Loire
    associated with the thesis of Samir Rezki (2014-2017)

    Unlike the phytopathogenic fungus Alternaria brassicicola, the phytopathogenic bacterium Xanthomonas campestris pv. campestris has no significant effect on the composition of the seed microbiota.

    Potential benefit:

    Identify populations that can compete with phytopathogenic agents for use as biocontrol agents.


    The genotype of the plant does not significantly influence the composition of microbial communities. On the other hand, the work showed an effect of the production area on the composition of the microbiota.

    → The genotype of the host plant does not seem to be a good lever to play on the compositions of the seed microbioal communities.

     Mathieu Barret
    matthieu.barret @ inra.fr




    Where and when to bring the treatment ?

    What are the factors, in the plant and the fungus, that control the transmission of the phytopathogenic fungus from the seed to the seedling?

    Patharaseed project (2014-2016) including the thesis of Elodie Belmas (2014-2017) – funded by Un. of Angers

    Pathosystem model: Arabidopsis thaliana - Alternaria brassicicola.

    • To identify, by transcriptomic studies, the stages of germination where the seedling defends iitself most  and where the fungus is the most aggressive.
    • Locate the fungus in the seed during the germination stages (technical platforms IMAC and SCIAM).
    Potential benefit:

    Helping agro-suppliers develop more efficient products and apply them at the right time to reduce doses of treatments.

    Philippe Grappin
    philippe.grappin @ agrocampus-ouest.fr



    Health and germination, a compromise to be found!

    XanthoMed project (2015-2016) – funded by INRA

    The seeds possess defense capacities against phytopathogenic agents. These defensive mechanisms vary from genotype to genotype, and can impact the acquisition of their germinative quality during their maturation phase.

    BASIS project (2017-2018) – funded by RFI Objectif Végétal

    • Identify seed defense mechanisms,
    • Understand the physiological and molecular effects of these mechanisms on the germinative quality of the seeds.
    Potential benefit:

    To obtain seeds capable of defending against the phytopathogenic agents while minimizing the loss of germinative quality.

    Jérôme Verdier
    jerome.verdier @ inra.fr




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    Looking for partners?

    Two contacts to support your projects:


    • Aurore Gautier,

    contact to support your R&D projects land to put you through

    aurore.gauthier @ vegepolys.eu


    • Tanegmart Redjala,

    close interface with the laboratories of the Research Federative Structure Quasav.

    tanegmart.redjala @ univ-angers.fr